The isolated lab for Frankenstein allows the mad scientist to conduct all these experiments and eventually create the monster that haunts the town later on, where as in Scream the isolated setting creates a last stand situation for the victims where there is no escape and you can only rely on yourself for survival.
This isolated situation makes the characters morph to flesh out true human nature, where men will play the god they desire and the greed and insanity of people jailed in the mind break its way out. The detached location increases the tension of fear, where we know no one is around to stop Frankenstein's experiment, and no one is ever going to arrive to help out the teenagers escape the blade of the killer. That these victims are truly alone and their death will be a remorseful one.
The use of a severed location from society is a common convention in the horror genre and is much expected by an audience for action to take part in. When someone leaves to go get a beer, they detach themselves from others and then as expected and dreaded the killer comes out of the darkness to finish her off.
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